For either indication and particularly when employing continuous intravenous infusion, the setting should include continuous monitoring of the ECG and frequent measurement of blood pressure. A defibrillator and emergency equipment should be readily available. Because of potential physical incompatibilities, it is recommended that diltiazem hydrochloride not be mixed with any other drugs in the same container. In addition, events such as myocardial infarction have been observed which are not readily distinguishable from the natural history of the disease in these patients. BENZODIAZEPINES. Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and Cmax by 2-fold, compared to placebo. order unisom usage unisom
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Tmax of buspirone were not significantly affected by diltiazem. Our Cartia XT diltiazem hydrochloride Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Your doctor may gradually increase your dose. Follow your doctor's instructions carefully. Take Diltiazem Hydrochloride Extended-Release Tablets once a day at approximately the same time. Do not chew or crush the tablet.
Studies have shown a slight increase in the rate of absorption of diltiazem hydrochloride extended-release capsules USP Once-a-day dosage when ingested with a high-fat breakfast; therefore, administration in the morning on an empty stomach is recommended. Digitalis: Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. These studies have revealed, in one species or another, a propensity to cause abnormalities of the skeleton, heart, retina, and tongue. Also observed were reductions in early individual pup weights and pup survival, prolonged delivery, and increased incidence of stillbirths.
Cartia XT is available in form. Hypotension. Decreases in blood pressure associated with diltiazem hydrochloride therapy may occasionally result in symptomatic hypotension. This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding. In a randomized, double-blind, parallel-group, dose-response study involving 478 patients with essential hypertension, evening doses of Cardizem LA 120, 240, 360, and 540 mg were compared to placebo and to 360 mg administered in the morning. Cardiovascular: Asystole, atrial flutter, AV block first degree, AV block second degree, bradycardia, chest pain, congestive heart failure, sinus pause, sinus node dysfunction, syncope, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia.
Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tinnitus, tremor. There are not adequate studies to show that this drug is safe in pregnant women. Similar findings were observed for standing systolic and diastolic blood pressures. The trough 24 hours after a dose antihypertensive effect of diltiazem hydrochloride extended-release capsule retained more than one-half of the response seen at peak 3-6 hours after administration. SINGLE-DOSE CONTAINERS. DISCARD UNUSED PORTION. Controlled and uncontrolled domestic studies suggest that concomitant use of diltiazem hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. In vitro, propranolol appears to be displaced from its binding sites by diltiazem. High-degree AV Block: Treat as for bradycardia above. Fixed high-degree AV block should be treated with cardiac pacing. zyprexa
Tiazac also reduced blood pressure in a linear dose-related manner. What other drugs will affect diltiazem? Diltiazem is excreted in breast milk, so women should not take it while breastfeeding. When compared to a regimen of immediate-release tablets at steady-state, approximately 93% of drug is absorbed from the diltiazem hydrochloride extended-release capsules, USP formulation. When diltiazem hydrochloride extended-release capsules, USP were coadministered with a high fat content breakfast, the extent of diltiazem absorption was not affected; T max, however, occurred slightly earlier. Ask your pharmacist about using those products safely. It was approved by the Food and Drug Administration FDA in 1982. Ask your pharmacist about using these products safely. Diltiazem slows the ventricular rate in patients with a rapid ventricular response during atrial fibrillation or atrial flutter. Oral administration of diltiazem with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. In vitro, propranolol appears to be displaced from its binding sites by diltiazem. Events observed following diltiazem overdose included bradycardia, hypotension, heart block, and cardiac failure. Subsequent intravenous bolus doses should be individualized for each patient. The usual dosage range studied in clinical trials was 120 to 540 mg once daily. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Cardiovascular: Palpitations, AV block, sinus bradycardia, bigeminal extrasystole, angina pectoris, hypertension, hypotension, myocardial infarct, myocardial ischemia, syncope, vasodilatation, ventricular extrasystole. Diltiazem may also be used for purposes not listed in this medication guide. Atrial Fibrillation or Atrial Flutter. Temporary control of rapid ventricular rate in atrial fibrillation or atrial flutter. It should not be used in patients with atrial fibrillation or atrial flutter associated with an accessory bypass tract such as in Wolff-Parkinson-White WPW syndrome or short PR syndrome.
Other medications can affect the removal of diltiazem from your body, which may affect how this medication works. Examples include cimetidine, quinidine, St. John's wort, azole antifungals such as ketoconazole, macrolide antibiotics such as erythromycin, rifamycins including rifabutin and rifampin. What happens if I miss a dose? Take this by without food, usually once daily before or as directed by your doctor. Swallow the capsules whole. not crush or chew the capsules. Doing so can release all of the drug at once and may increase your risk of side effects. Several literature reports have identified cases of diltiazem hydrochloride overdose, some with multiple drug ingestion, with both fatal and non-fatal outcomes. The reported events affected multiple body systems including the cardiovascular system bradycardia, complete heart block, asystole, cardiac failure, arrhythmia, atrial fibrillation, palpitations, hypotension, ischemia, ECG changes respiratory system respiratory failure, hypoxia, dyspnea, pulmonary edema central nervous system loss of consciousness, convulsions, dizziness, confusion, agitation gastrointestinal system nausea, vomiting skin and appendages increased sweating and other systems hypotonia, iliac artery thrombosis, metabolic acidosis, increased blood glucose. The administration of ipecac to induce vomiting and activated charcoal to reduce drug absorption have been advocated as initial means of intervention. AV conduction. In subacute and chronic dog and rat studies designed to produce toxicity, high oral doses of diltiazem were associated with hepatic damage. Due to extensive metabolism, plasma concentrations after a standard dose of diltiazem can vary over tenfold, which significantly limits their value in evaluating cases of overdosage. During dynamic exercise, increases in diastolic pressure are inhibited while maximum achievable systolic pressure is usually reduced. Heart rate at maximum exercise does not change or is slightly reduced. Actual treatment and dosage should depend on the severity of the clinical situation as well as the judgment and experience of the treating physician. This value was shown to be similar to the 40% systemic availability reported following administration of an immediate release diltiazem hydrochloride formulation. ponstel suppository price philippines
Hypertension: Diltiazem produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normotensives. Dosage needs to be adjusted by titration to individual patient needs. When used as monotherapy, usual starting doses are 120 to 240 mg once daily. Maximum antihypertensive effect is usually observed by 14 days of chronic therapy; therefore, dosage adjustments should be scheduled accordingly. The usual dosage range studied in clinical trials was 120 to 540 mg once daily. Current clinical experience with 540 mg dose is limited; however, the dose may be increased to 540 mg once daily. In the event of overdose or exaggerated response, appropriate supportive measures should be employed in addition to gastrointestinal decontamination. Diltiazem does not appear to be removed by peritoneal or hemodialysis. Limited data suggest that plasmapheresis or charcoal hemoperfusion may hasten diltiazem elimination following overdose. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC. Acute Hepatic Injury. Mild elevations of serum transaminases with and without concomitant elevation in alkaline phosphatase and bilirubin have been observed in clinical studies. Such elevations were usually transient and frequently resolved even with continued diltiazem treatment. In rare instances, significant elevations in alkaline phosphatase, LDH, SGOT, SGPT, and other phenomena consistent with acute hepatic injury have been noted. These reactions tended to occur early after therapy initiation 1 to 6 weeks and have been reversible upon discontinuation of drug therapy.
Following single intravenous injection of diltiazem hydrochloride, however, plasma concentrations of N-mono-desmethyldiltiazem and desacetyldiltiazem, two principal metabolites found in plasma after oral administration, are typically not detected. These metabolites are observed, however, following 24 hour constant rate intravenous infusion. Total radioactivity measurement following short IV administration in healthy volunteers suggests the presence of other unidentified metabolites which attain higher concentrations than those of diltiazem and are more slowly eliminated; half-life of total radioactivity is about 20 hours compared to 2 to 5 hours for diltiazem. Urogenital System: Kidney failure, pyelonephritis, urinary tract infection. Apotex Inc. Apotex Corp. Carbamazepine. Concomitant administration of oral diltiazem with carbamazepine has been reported to result in elevated plasma levels of carbamazepine by 40 to 72% resulting in toxicity in some cases. Patients receiving these drugs concurrently should be monitored for a potential drug interaction. The effects of Cardizem LA on angina were evaluated in a randomized, double-blind, parallel-group, dose-response trial of 311 patients with chronic stable angina. Evening doses of 180, 360, and 420 mg were compared to placebo and to 360 mg administered in the morning. All doses of Cardizem LA administered at night increased exercise tolerance when compared with placebo after 21 hours. The mean effect, placebo-subtracted, was 20 to 28 seconds for all three doses, and no dose-response was demonstrated. Cardizem LA, 360 mg, given in the morning, also improved exercise tolerance when measured 25 hours later. As expected, the effect was smaller than the effects measured only 21 hours following nighttime administration. Cardizem LA had a larger effect to increase exercise tolerance at peak serum concentrations than at trough. Diltiazem-associated prolongation of the AH interval is not more pronounced in patients with first-degree heart block. In patients with sick sinus syndrome, diltiazem significantly prolongs sinus cycle length up to 50% in some cases. Intravenous diltiazem in doses of 20 mg prolongs AH conduction time and AV node functional and effective refractory periods approximately 20%. Pharmacokinetics and Metabolism: Diltiazem is well absorbed from the gastrointestinal tract, and is subject to an extensive first-pass effect. When given as an immediate release oral formulation, the absolute bioavailability compared to intravenous administration of diltiazem is approximately 40%. Diltiazem undergoes extensive hepatic metabolism in which 2% to 4% of the unchanged drug appears in the urine. Total radioactivity measurement following short IV administration in healthy volunteers suggests the presence of other unidentified metabolites which attain higher concentrations than those of diltiazem and are more slowly eliminated; half-life of total radioactivity is about 20 hours compared to 2 to 5 hours for diltiazem. In vitro binding studies show diltiazem HCl is 70% to 80% bound to plasma proteins. Competitive in vitro ligand binding studies have also shown diltiazem HCl binding is not altered by therapeutic concentrations of digoxin, HCTZ, phenylbutazone, propranolol, salicylic acid, or warfarin. BID diltiazem SR resulted in a 5-fold increase in mean simvastatin AUC vs. simvastatin alone. Subjects with increased average steady-state exposures of diltiazem showed a greater fold increase in simvastatin exposure. Computer-based simulations showed that at a daily dose of 480 mg of diltiazem, an 8- to 9-fold mean increase in simvastatin AUC can be expected. Safety and effectiveness in pediatric patients have not been established. Red No. 28, and titanium dioxide. The 120 mg dosage form contains pregelatinized starch. Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction. A patient with Prinzmetal's angina developed periods of asystole 2 to 5 seconds after a single 60 mg dose of diltiazem. To consult their physician if they become pregnant while taking Diltiazem Hydrochloride Extended-Release Tablets or plan to become pregnant. price of lisinopril oral
AUC and Cmax versus lovastatin alone. Category C: Reproduction studies have been conducted in mice, rats, and rabbits. LA is supplied as white, capsule-shaped tablets debossed with "B" on one side and the diltiazem content mg on the other. Diltiazem may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Digitalis: Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. Since there have been conflicting results regarding the effects of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization. Like other calcium channel antagonists, diltiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect in isolated preparations. In the intact animal, prolongation of the AH interval can be seen at higher doses. After oral administration, diltiazem undergoes extensive metabolism in man by deacetylation, N-demethylation, and O-demethylation via cytochrome P-450 oxidative metabolism in addition to conjugation. Metabolites N-monodesmethyldiltiazem, desacetyldiltiazem, desacetyl-N-monodesmethyldiltiazem, desacetyl-O-desmethyldiltiazem, and desacetyl-N, O-desmethyldiltiazem have been identified in human urine. Following oral administration, 2% to 4% of the unchanged diltiazem appears in the urine. Drugs which induce or inhibit hepatic microsomal enzymes may alter diltiazem disposition. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Diltzac Diltiazem Hydrochloride Extended-Release Capsules, USP Once-a-day dosage 240 mg are available for oral administration as hard gelatin capsules with a blue green opaque body and a blue violet opaque cap. “APO 240” is imprinted on each capsule in black ink. Patients should be cautioned that the diltiazem hydrochloride extended-release USP Once-a-day dosage capsules should not be opened, chewed or crushed, and should be swallowed whole. Urogenital System: Cystitis, kidney calculus, impotence, dysmenorrhea, vaginitis, prostate disease. Cardizem LA may be used alone or in combination with other antihypertensive medications. There was also no mutagenic response in in vitro bacterial tests. No intrinsic effect on fertility was observed in rats. Take diltiazem with a full glass of water.
Of cases with known outcome, most patients recovered and in cases with a fatal outcome, the majority involved multiple drug ingestion. Diltiazem hydrochloride has an additive antihypertensive effect when used with other antihypertensive agents. Therefore, the dosage of diltiazem hydrochloride or the concomitant antihypertensives may need to be adjusted when adding one to the other. Cardiac Failure: Administer inotropic agents dopamine or dobutamine and diuretics. Monitor for effects on heart rate and cardiac conduction. In renal and cardiac transplant recipients, a reduction of cyclosporine trough dose ranging from 15% to 48% was necessary to maintain concentrations similar to those seen prior to the addition of diltiazem. If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued. The effect of cyclosporine on diltiazem plasma concentrations has not been evaluated. Diltiazem prolongs the sinus cycle length. It has no effect on the sinus node recovery time or on the sinoatrial conduction time in patients without SA nodal dysfunction. Cardizem LA is formulated as a once-a-day extended-release tablet for oral administration containing 120 mg, 180 mg, 240 mg, 300 mg, 360 mg or 420 mg of diltiazem hydrochloride. Worsening of congestive heart failure has been reported in patients with preexisting impairment of ventricular function. Experience with the use of diltiazem hydrochloride in combination with beta-blockers in patients with impaired ventricular function is limited. Caution should be exercised when using this combination. Diltiazem Hydrochloride Extended-Release Tablet are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including this drug. In short-term, double-blind, placebo-controlled clinical trials diltiazem hydrochloride extended-release capsules, USP demonstrated a dose-related antihypertensive response among patients with mild to moderate hypertension. In one parallel-group study of 198 patients Diltiazem hydrochloride extended-release capsules, USP was given for four weeks. proventil
In vivo release of diltiazem occurs throughout the gastrointestinal tract, with controlled release still occurring for up to 24 hours after administration, as determined by radio-labeled methods. As the once daily dose of Dilacor XR was increased, departures from linearity were noted. AUC versus simvastatin alone. Your pharmacist can provide more information about diltiazem. Angina. Diltiazem has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal workloads. Diltiazem has been shown to be a potent dilator of coronary arteries, both epicardial and subendocardial. Spontaneous and ergonovine-induced coronary artery spasm are inhibited by diltiazem. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. Nervous System: Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tinnitus, tremor. Benzodiazepines: Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3- to 4-fold and the C max by 2-fold, compared to placebo. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Diltiazem can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
The usual dosage range studied in clinical trials was 180 mg to 480 mg once daily. AUC compared with simvastatin alone. Diltzac diltiazem hydrochloride extended-release capsules, USP once-a-day dosage contain diltiazem hydrochloride in extended release pellets at doses of 120, 180, 240, 300 and 360 mg. In addition, each capsule also contains the following inactive ingredients: carboxymethylcellulose sodium, eudragit, methylcellulose, microcrystalline cellulose and talc. Each capsule shell contains gelatin and titanium dioxide. Beta-Blockers: Controlled and uncontrolled domestic studies suggest that concomitant use of diltiazem hydrochloride and beta-blockers is usually well-tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. As with all drugs, care should be exercised when treating patients with multiple medications. Diltiazem hydrochloride undergoes biotransformation by cytochrome P-450 mixed function oxidase. Co-administration of diltiazem hydrochloride with other agents which follow the same route of biotransformation may result in the competitive inhibition of metabolism. probalan does order matter
Diltiazem does not appear to be removed by peritoneal or hemodialysis. Limited data suggest that plasmapheresis or charcoal hemoperfusion may hasten diltiazem elimination following overdose. Ranitidine produced smaller, non-significant increases. Therefore, the potential for these dermatologic reactions exists following exposure to intravenous diltiazem. Should a dermatologic reaction persist, the drug should be discontinued. If there is no response to vagal blockade administer isoproterenol cautiously. Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with diltiazem hydrochloride see . As with all drugs, care should be exercised when treating patients with multiple medications. Diltiazem hydrochloride undergoes biotransformation by cytochrome P-450 mixed function oxidase. Co-administration of diltiazem hydrochloride with other agents which follow the same route of biotransformation may result in the competitive inhibition of metabolism. By causing vascular smooth muscle relaxation, CCBs decrease systemic vascular resistance, which lowers arterial blood pressure. These drugs primarily affect arterial resistance vessels, with only minimal effects on venous capacitance vessels. Administration of diltiazem hydrochloride tablets with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. Do not split, crush or chew tablets. Body as a Whole: Pain, unevaluable reaction, neck pain, neck rigidity, fever, chest pain, malaise. Dermatological events see may be transient and may disappear despite continued use of diltiazem hydrochloride tablets. The therapeutic effects of diltiazem hydrochloride are believed to be related to its ability to inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. Do not share this medication with others. Some doctors have also prescribed diltiazem to prevent migraines, though the evidence supporting its use among people with migraines is not universally accepted.
Diltiazem Hydrochloride Extended-Release Tablets are supplied as white, capsule-shaped tablets debossed with "B" on one side and the diltiazem content mg on the other. Diltiazem has been shown to be a potent dilator of coronary arteries, both epicardial and subendocardial. Spontaneous and ergonovine-induced coronary artery spasms are inhibited by diltiazem. Bradycardia frequently responded favorably to atropine as did heart block, although cardiac pacing was also frequently utilized to treat heart block. Fluids and vasopressors were used to maintain blood pressure and in cases of cardiac failure, inotropic agents were administered. Exercise Tolerance Test ETT and a reduction in rates of anginal attacks based on individual patient diaries. The improvement in total exercise time using the Bruce protocol measured at trough exercise periods, for placebo, 120 mg, 240 mg, and 480 mg, was 20, 37, 49, and 56 seconds, respectively. Significant elevations in liver enzymes such as alkaline phosphatase, LDH, AST SGOT ALT SGPT and signs of acute hepatic injury have been reported with diltiazem therapy. These reactions tended to occur early after therapy initiation 1 to 8 weeks and have been reversible upon discontinuation of drug therapy. Mild elevations of transaminases with and without concomitant elevation in alkaline phosphatase and bilirubin have also been observed. Such elevations were usually transient and frequently resolved even with continued diltiazem treatment. The 30 mg tablets are white, film-coated, round, unscored tablets debossed with M over 23 on one side of the tablet and blank on the other side. Diltiazem hydrochloride is a nondihydropyridine calcium channel blocker slow channel blocker or calcium antagonist. Swallow diltiazem hydrochloride tablets whole; do not split, crush, or chew the tablets. Diltiazem is an inhibitor of CYP3A4 and has been shown to increase significantly the AUC of some statins. The risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4 is increased with concomitant use of diltiazem. When possible, use a non-CYP3A4-metabolized statin with diltiazem. Otherwise, reduce the dose for both diltiazem and the statin and monitor for signs and symptoms of muscle toxicity. The infusion may be maintained for up to 24 hours. Dilacor XR capsules contain multiple units of diltiazem HCl extended-release 60 mg, resulting in 120 mg, 180 mg, or 240 mg dosage strengths allowing for the controlled release of diltiazem HCl over a 24-hour period. udol.info trazodone
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The toxic dose in man is not known. In a 10-subject randomized, open label, 4-way cross-over study, coadministration of diltiazem 120 mg BID diltiazem SR for 2 weeks with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin alone. In the same study, there was no significant change in 20 mg single dose pravastatin AUC and C max during diltiazem coadministration. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension for example, patients with diabetes or hyperlipidemia and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. purchase now cheapest nimotop payment nimotop
CCBs are used to treat hypertension, angina and arrhythmias. Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol, and chloroform. It has a molecular weight of 450. Diltiazem hydrochloride is a calcium ion cellular influx inhibitor slow channel blocker.
The use of intravenous diltiazem for control of ventricular response in patients with supraventricular arrhythmias should be undertaken with caution when the patient is compromised hemodynamically. In addition, caution should be used in patients taking other drugs that decrease peripheral resistance, intravascular volume, myocardial contractility or conduction. What should I discuss with my healthcare provider before taking diltiazem? Gastrointestinal: Constipation, elevated SGOT or alkaline phosphatase, nausea, vomiting. Bradycardia frequently responded favorably to atropine as did heart block, although cardiac pacing was also frequently utilized to treat heart block. Fluids and vasopressors were used to maintain blood pressure, and in cases of cardiac failure, inotropic agents were administered.
When necessary, titration may be carried out over a 7 to 14 day period. What is diltiazem Cardizem? Diltiazem hydrochloride may be safely co-administered with short- and long-acting nitrates.